Obes Rev. Epub Sep 6. PMID: FDA label Depakote divalproex sodium [cited July 13] 3. Shen H, et al. Bowden CL. Substitution of immediate-release valproic acid for divalproex sodium for adult psychiatric inpatients. Psychiatr Serv.
Rahman M, Nguyen H. Valproic Acid. In: StatPearls [Internet]. Status Epilepticus. Consequences of antiepileptic drug withdrawal: a randomized, double-blind study Akershus Study.
Epub Sep Psychosocial outcomes of antiepileptic drug discontinuation. Ranganathan LN, Ramaratnam S. Rapid versus slow withdrawal of antiepileptic drugs.
Cochrane Database Syst Rev. Valproate-withdrawal induced migraine. Yablon LA, Mauskop A. Magnesium in headache. In: Vink R, Nechifor M, editors. Magnesium in the Central Nervous System [Internet].
Withdrawal symptoms from phenytoin, carbamazepine and sodium valproate. J Neurol Neurosurg Psychiatry. Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats. PLoS One. Published Jun T reatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in rats.
Epub Jun Thisted E, Ebbesen F. Malformations, withdrawal manifestations, and hypoglycaemia after exposure to valproate in utero. Arch Dis Child. National Center for Biotechnology Information Patel AR, Nagalli S. Valproate Toxicity. Motl is currently certified by the American Board of Psychiatry and Neurology in Psychiatry, and Board eligible in Neurology and licensed in the state of Arizona. He holds a Bachelor of Science degree with a major in biology and minors in chemistry and philosophy.
View Bio. Diane is an avid supporter and researcher of natural mental health strategies. Diane received her medical writing and science communication certification through Stanford University and has published over 3 million words on the topics of holistic health, addiction, recovery, and alternative medicine.
She has proudly worked with the Alternative to Meds Center since its inception and is grateful for the opportunity to help the founding members develop this world-class center that has helped so many thousands regain natural mental health. Fill out the form below to connect with us today! You may opt out at any time. Hidden Yes! I want your newsletter. Name This field is for validation purposes and should be left unchanged. Can you imagine being free from medications, addictive drugs, and alcohol?
This is our goal and we are proving it is possible every day! Call Mon-Sun:. This entry was posted in Antipsychotic on August 5, by Diane Ridaeus. Fact Checked. What is Depakote Used For? Depakote withdrawal symptoms may include: Status epilepticus — a neurological emergency condition in epileptic patients where sudden Depakote withdrawal can cause seizures that do not stop. Rapid 6 weeks taper results were compared with slow 9 months taper outcomes.
The small sample size and lack of other details did not allow definite conclusions to be derived on the optimum rate of anticonvulsive withdrawal, and the authors called for further studies on the subject in both children and adults.
Depakote withdrawal is a largely neglected topic. Valproic acid may help to control your condition but will not cure it. Continue to take valproic acid even if you feel well. Do not stop taking valproic acid without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood or if you find out that you are pregnant. If you suddenly stop taking valproic acid, you may experience a severe, long-lasting and possibly life-threatening seizure.
Your doctor will probably decrease your dose gradually. Valproic acid is also sometimes used to treat outbursts of aggression in children with attention deficit hyperactivity disorder ADHD; more difficulty focusing or remaining still or quiet than other people who are the same age. Talk to your doctor about the possible risks of using this medication for your condition. This medication is sometimes prescribed for other uses. Ask your doctor or pharmacist for more information.
Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Valproic acid may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. Keep this medication in the container it came in, tightly closed, and out of reach of children.
Store it at room temperature, away from excess heat and moisture not in the bathroom. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.
However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach. In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at If you are taking the sprinkle capsules, you may notice the medication beads in your stool. This is normal and does not mean that you did not get the full dose of medication.
If you have diabetes and your doctor has told you to test your urine for ketones, tell the doctor that you are taking valproic acid. Valproic acid can cause false results on urine tests for ketones. Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking valproic acid. Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies. Valproic Acid pronounced as val proe' ik. Why is this medication prescribed? How should this medicine be used?
Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow? Divalproex sodium can cause liver failure that may be fatal, especially in children under age 2 and in people with liver problems caused by a genetic mitochondrial disorder.
Some people have thoughts about suicide while taking divalproex sodium. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Using divalproex sodium during pregnancy may increase the risk of serious birth defects that can develop early in pregnancy, even before you know you are pregnant.
Using this medicine during pregnancy can also affect cognitive ability reasoning, intelligence, problem-solving later in your child's life. However, having a seizure during pregnancy could harm both the mother and the baby. If you take divalproex sodium for seizures or manic episodes: The benefit of preventing seizures or manic episodes may outweigh any risks posed by this medicine. There may be other medications that are safer to use during pregnancy. Do not start or stop taking divalproex sodium without your doctor's advice.
Do not use divalproex sodium to prevent migraine headaches if you are pregnant or you could become pregnant. If you are not pregnant, use effective birth control to prevent pregnancy while using divalproex sodium. Tell your doctor if you start or stop using hormonal contraception that contains estrogen birth control pills, injections, implants, skin patches, and vaginal rings. Estrogen can interact with divalproex sodium and make it less effective in preventing seizures.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Drink plenty of water while you are taking this medication. Your dose may need to be changed if you do not get enough fluids each day. If you cannot swallow a sprinkle capsule whole, open it and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow the mixture right away. Do not save it for later use. In case of emergency, wear or carry medical identification to let others know you use divalproex sodium. Do not stop using divalproex sodium suddenly , even if you feel fine.
Follow your doctor's instructions about tapering your dose. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.
Do not take two doses at one time. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling.
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
Report any new or worsening symptoms to your doctor , such as: mood or behavior changes, depression, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive mentally or physically , or have thoughts about suicide or hurting yourself. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
0コメント